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Protocols: Siberian Ginseng (Eleutherococcus senticosus)

Psychoactive

Description: Native to northern parts of China, Japan Korea and Eastern Russia. 2000 year history of use. Not a traditional ginseng. Used by Soviet cosmonauts and Olympic athletes.

Method of Action: Differs from other forms of Ginseng. Does not contain panax-type ginsenosides and instead contains Eleutherococcus senticosus. Although it has been theorized that Ginseng augments adrenal steroidogenesis via the pituitary gland, actual studies have found an immunomodulating effect (as measured by IgG and IgM responses to either a primary or secondary challenge with sheep red blood cells) with stimulation of interferon production in vitro. Found to increase NK killer cell cytoylsis activity and antiviral activity (reduction in plaque-forming units of coxsackievirus B4 strain E2) during in vitro testing.

Indications and Usage: Fatigue; Compromised immune system; Climatic adaptation; Visual acuity. Improved subjective ratings of mood, vigor, and well being which was associated with increased physical activity and reduced weight have been reported in research literature along with hypoglycemic effects useful in the treatment of Type-2 Diabetes.

Contraindications: Common adverse effects of ginseng administration include hypertension, insomnia, nausea and vomiting, headache and epistaxis. Moderate infiltration of the dermis by mononuclear calls has been observed. May alter bleeding time and should not be used concomitantly with warfarin sodium. May increase cortisol levels resulting in increased anxiety and insomnia and is not recommended during period of acute stress and anxiety. Not recommended for women who have menstrual irregularities (has been known to cause vaginal bleeding attributed to a moderate estrogen effect), or for individuals with high blood pressure, or migraine headaches. Ginseng may be highly stimulating and cause tremulousness and manic episodes in patients being treated concomitantly with phenalzine sulfate. Likewise, ginseng products should not be used by persons with Bipolar Disorder, psychotic or thought-disordered conditions. Ginseng also should not be used with estrogens or corticosteriods because of possible additive effects. Ginseng has been associated with mastalgia with diffuse breast modularity. Ginseng has been associated with neonatal androgenization and use in pregnancy should be avoided at this time. May interfere with digoxin pharmacodynamically or with digoxin monitoring. Can affect blood glucose levels and should not be used in patients with diabetes mellitus.

Dosage and Administration: 180 to 360 mg daily (0.3% eleutheroside B and 0.5% of eleutheroside E) in divided doses. Taken in morning for two to three months followed by two week break.

Clinical Effect In: Several weeks.

Adverse Reactions: Fewest side effects of ginseng-class plants. High blood pressure. If you suspect that an herb or other supplement is making you sick, call the FDA's MedWatch hotline at 800-332-1088 or contact the agency via its website at http://www.fda.gov/medwatch.

Known Interactive Effects: Should be used cautiously with sedative-hypnotic agents as some studies report alteration of barbiturate-induced sleeping time.

Additional Considerations: There is tremendous content variation in commercial Ginseng products. Only 25% of studied commercial products actually contain Ginseng. Best adaptogen available especially for persons with existing anxiety and insomnia problems. Take in morning to avoid insomnia.

Warnings: The information above is provided for educational purposes and may not be construed as a medical prescription or as a substitute for the advice of your physician. Do not use this product without first consulting your physician especially if you are pregnant or lactating. Be advised that some herbs and dietary supplements can cause severe allergic reactions in some individuals and may also have an adverse result in conjunction with other medications, or treatments. You should regularly consult your physician in matters regarding your health and particularly in respect to symptoms and conditions which may require diagnosis or medical attention. Reevaluate use of this product after 6 months.

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