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Protocols: Phosphatidylserine

Description: Phosphatidylserine (PS) is a naturally occurring phospholipid which is found in the cell membrane of a wide variety of organisms including the human brain. PS has clearly been demonstrated to be involved in the modulation of neuronal excitability, message transduction and neurotransmitter activity including catecholamines and acetylcholine release, NMDA receptor density and muscarinic receptor density.

Method of Action: Various laboratory and clinical studies have demonstrated that chronic oral administration of Phosphatidylserine (PS) counteracts stress-induced activation of the hypothalamic-pituitary-adrenal axis in humans. Administration of PS blunts ACTH and cortisol responses to stress without affecting the rise in growth hormone or prolactin. Deficiencies in methyl donors such as SAMe, folic acid, vitamin B-12, or essential fatty acids can result in an inability of the brain to make sufficient PS.

May work by improving brain cell fluidity. Does not appear to alter levels of serotinin or other monoamine neurotransmitters. Has same beneficial effects on memory regardless of etiological cause.

Indications and Usage: Chronic fatigue; Anxiety disorders; Depression; Stress-related short-term memory deficits. Especially helpful in elderly populations where depression, memory deficits cognitive problems are present.

Contraindications: Do not use this product if you are pregnant or lactating without first seeking advice from your physician.

Dosage and Administration: Dosage range is from 50 to 100 mg daily taken three times daily. Dosage can sometimes be reduced to a maintenance level of 100 mg daily after full-effect has been achieved.

Clinical Effect In: Several weeks.

Adverse Reactions: None reported. If you suspect that an herb or other supplement is making you sick, call the FDA's MedWatch hotline at 800-332-1088 or contact the agency via its website at http://www.fda.gov/medwatch.

Known Interactive Effects: May theoretically interact with blood thinning agents including Ginkgo Biloba, aspirin, heparin, or coumadin.

Additional Considerations: Semi-synthetic product is manufactured from soy lecithin.

Warnings: The information above is provided for educational purposes and may not be construed as a medical prescription or as a substitute for the advice of your physician. Do not use this product without first consulting your physician especially if you are pregnant or lactating. Be advised that some herbs and dietary supplements can cause severe allergic reactions in some individuals and may also have an adverse result in conjunction with other medications, or treatments. You should regularly consult your physician in matters regarding your health and particularly in respect to symptoms and conditions which may require diagnosis or medical attention. Reevaluate use of this product after 6 months.

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